Table 4.
SARS-CoV2 infection, severe infection and death in patients treated with calcifediol (n = 134,703) and their matched controls (269,406)
| Outcome | Calcifediol treatment (n = 134,703) | Matched controls (n = 269,406) | Univariate analysis3 | Multivariate analysis4 | ||
|---|---|---|---|---|---|---|
| HR (CI 95%) | p | HR (CI 95%) | p | |||
| SARS-CoV2 infection1, n (%) | 5662 (4.2) | 11,401 (4.2) | 0.99 (0.96–1.03) | 0.646 | – | – |
| Severe COVID-192, n (%) | 1037 (0.8) | 2073 (0.8) | 1.00 (0.93–1.08) | 0.995 | – | – |
| COVID-19 mortality, n (%) | 934 (0.7) | 1859 (0.7) | 1.01 (0.93–1.09) | 0.908 | – | – |
1Positive PCR or clinical diagnosis of SARS-CoV2 infection
2Composite outcome of need for non-invasive mechanical ventilation, orotracheal intubation, mechanical ventilation, intensive care unit admission or death
3Unadjusted Cox regression analysis
4Cox regression analysis controlling for all covariates