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. 2021 Jul 17;23:74. doi: 10.1186/s13058-021-01453-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Usage of chemotherapy in Oncotype DX users between 2004 and 2015. A Oncotype DX usage rates among patients undergoing chemotherapy (triangles) and overall Oncotype DX usage rate (circles). B Percentage of risk groups (high-, intermediate-, and low-risk) classified by Oncotype DX test results. C Percentage of chemotherapy usage between high-, intermediate-, and low-risk Oncotype DX groups. D Chemotherapy usage among patients with ER+HER2− and ER+HER2+ breast cancer, stratified by Oncotype DX usage. For A, C, and D, usage rates were calculated based on the total number of patients within each indicated patient subgroup