Table 6.
Logistic regression of risk factors of clinical candidiasis throughout the treatment
| Patient characteristics | Univariate | Multivariate | ||
|---|---|---|---|---|
| OR (95 %CI) | p value | OR (95 %CI) | p value | |
| Sex | 0.038* | 10.93 (2.26–52.86) | 0.003# | |
| Male | 1 | |||
| Female | 2.71 (1.06–6.95) | |||
| Age | 1.02 (0.98–1.07) | 0.269 | ||
| Underlying disease | ||||
| DM | 2.45 (0.39–15.52) | 0.341 | ||
| HT | 1.27 (0.48–3.36) | 0.629 | ||
| Tumor site | ||||
| Nasopharynx | 1 | |||
| Oropharynx | 1.16 (0.38–3.55) | 0.790 | ||
| Oral cavity | 3.05 (1.04-9.00) | 0.043 | ||
| Radiotherapy option | ||||
| Postoperative RT | ||||
| Radical RT |
1 0.51 (0.20–1.29) |
0.158* | ||
| Dose of radiotherapy (Gy) | 0.90 (0.81–1.01) | 0.066* | ||
| CCRT | 1.72 (0.55–5.45) | 0.354 | ||
| CCRT cycle | 0.34 (0.54–1.29) | 0.419 | ||
| Type of chemotherapy agent | ||||
| Cisplatin | 1 | |||
| Carboplatin | 0.63 (0.24–1.68) | 0.357 | ||
| Personal history | ||||
| Smoking | ||||
| Never used | 1 | |||
| Using currently | 2.56 (0.83–7.85) | |||
| Alcohol | ||||
| Never used | 1 | 0.100* | ||
| Using currently | 0.68 (0.28–1.67) | 0.400 | 12.57 (2.19–72.29) | 0.005# |
| Oral status | ||||
| Oral hygiene | ||||
| Excellent/good | 1 | |||
| Fair/poor | 0.57 (0.16–1.98) | 0.373 | ||
| Denture wearer | 0.75 (0.17–3.23) | 0.700 | ||
| Mouthwash using | ||||
| Non-benzydamine HCl | 1 | |||
| Benzydamine HCl | 0.44 (0.15–1.28) | 0.133* | ||
| 2% viscous lidocaine solution using | 2.03 (0.74–5.58) | 0.172* | ||
| Xerostomia | 2.03 (0.72–5.71) | 0.180* | ||
| Mucositis | 4.13 (1.60-10.69) | 0.003* | ||
| Candida colonization before RT | 2.13 (0.87–5.21) | 0.100* | ||
*p < 0.25, #significant risk factors