Table 2.
HR (95% CIs) of pancreatic cancer, by quartile of each fatty acid
| Fat intake | Quartiles of fat intakes | P-Trend | Continuous | |||
|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | |||
| Total fat | 0.62 | 1.004(0.98-1.02) | ||||
| Range (gday-1) | 7.46-60.03 | 60.03-73.57 | 73.57-88.02 | 88.02-304.73 | ||
| Median (gday-1) | 50.46 | 67.25 | 80.19 | 99.88 | ||
| Cases/controls | 20/11722 | 18/11732 | 14/11730 | 22/11720 | ||
| Multivariate HR (95% CI) | 1 | 0.91(0.48-1.71) | 0.54(0.24-1.21) | 1.07(0.44-2.59) | ||
| SFAa | ||||||
| 4:0 | 0.35 | 0.91 (0.76-1.10) | ||||
| Range (gday-1) | 0.00-0.25 | 0.25-0.39 | 0.39-0.63 | 0.63-9.99 | ||
| Median (gday-1) | 0.17 | 0.31 | 0.49 | 1.03 | ||
| Cases/controls | 20/11720 | 13/11732 | 23/11724 | 18/11727 | ||
| Multivariate HR (95% CI) | 1 | 0.70(0.34-1.44) | 1.001(0.51-1.92) | 0.73(0.36-1.46) | ||
| 6:0 | 0.04 | 0.82 (0.68-0.99) * | ||||
| Range (gday-1) | 0.00-0.19 | 0.19-0.30 | 0.30-0.52 | 0.52-9.99 | ||
| Median (gday-1) | 0.14 | 0.24 | 0.38 | 3.74 | ||
| Cases/controls | 23/11719 | 14/11727 | 25/11733 | 12/11732 | ||
| Multivariate HR (95% CI) | 1 | 0.64(0.32-1.28) | 0.81(0.43-1.53) | 0.51(0.24-1.04) | ||
| 8:0 | 0.01 | 0.84(0.74-0.96) * | ||||
| Range (gday-1) | 0.00-0.18 | 0.18-0.27 | 0.27-0.55 | 0.55-10.00 | ||
| Median (gday-1) | 0.13 | 0.22 | 0.35 | 5.72 | ||
| Cases/controls | 23/11709 | 17/11736 | 23/11725 | 11/11734 | ||
| Multivariate HR (95% CI) | 1 | 0.70(0.37-1.32) | 0.65(0.34-1.24) | 0.38(0.18-0.79)* | ||
| 10:0 | 0.55 | 0.93 (0.75-1.16) | ||||
| Range (gday-1) | 0.00-0.36 | 0.36-0.59 | 0.59-0.90 | 0.90-9.99 | ||
| Median (gday-1) | 0.24 | 0.47 | 0.72 | 1.25 | ||
| Cases/controls | 19/11722 | 14/11727 | 20/11731 | 21/11724 | ||
| Multivariate HR (95% CI) | 1 | 0.82(0.40-1.68) | 1.09(0.56-2.13) | 0.82(0.40-1.65) | ||
| 12:0 | 0.37 | 0.89 (0.69-1.14) | ||||
| Range (gday-1) | 0.00-0.29 | 0.29-0.46 | 0.46-0.69 | 0.69-9.99 | ||
| Median (gday-1) | 0.21 | 0.37 | 0.55 | 0.94 | ||
| Cases/controls | 20/11722 | 10/11733 | 22/11724 | 22/11725 | ||
| Multivariate HR (95% CI) | 1 | 0.55(0.25-1.19) | 1.13(0.58-2.18) | 0.81(0.40-1.64) | ||
| 14:0 | 0.78 | 1.04 (0.77-1.41) | ||||
| Range (gday-1) | 0.10-0.85 | 0.85-1.32 | 1.32-1.93 | 1.93-9.91 | ||
| Median (gday-1) | 0.57 | 1.08 | 1.59 | 2.47 | ||
| Cases/controls | 17/11726 | 13/11732 | 19/11726 | 25/11720 | ||
| Multivariate HR (95% CI) | 1 | 0.88(0.41-1.85) | 1.17(0.57-2.43) | 1.06(0.47-2.37) | ||
| 16:0 | 0.30 | 0.91 (0.77-1.08) | ||||
| Range (gday-1) | 1.09-8.20 | 8.20-10.26 | 10.26-12.67 | 12.67-54.39 | ||
| Median (gday-1) | 6.84 | 9.27 | 11.34 | 14.73 | ||
| Cases/controls | 19/11725 | 13/11732 | 19/11726 | 23/11721 | ||
| Multivariate HR (95% CI) | 1 | 0.53(0.24-1.18) | 0.72(0.32-1.63) | 0.68(0.21-2.12) | ||
| 18:0 | 0.01 | 1.03(1.01-1.07) | ||||
| Range (gday-1) | 0.61-18.17 | 18.17-24.65 | 24.65-30.90 | 30.90-234.84 | ||
| Median (gday-1) | 12.58 | 21.68 | 27.68 | 35.78 | ||
| Cases/controls | 16/11728 | 18/11726 | 14/11732 | 26/11718 | ||
| Multivariate HR (95% CI) | 1 | 1.21(0.58-2.54) | 1.24(0.54-2.87) | 2.57(1.03-6.41)* | ||
| 20:0 | 0.33 | - | ||||
| Range (gday-1) | 0.00-0.09 | 0.09-0.14 | 0.14-0.18 | 0.18-1.08 | ||
| Median (gday-1) | 0.06 | 0.12 | 0.16 | 0.21 | ||
| Cases/controls | 21/11722 | 10/11712 | 20/11738 | 23/11732 | ||
| Multivariate HR (95% CI) | 1 | 0.53(0.24-1.18) | 0.97(0.47-2.01) | 1.25(0.53-2.92) | ||
| 22:0 | 0.01 | - | ||||
| Range (gday-1) | 0.00-0.08 | 0.08-0.11 | 0.11-0.15 | 0.15-1.08 | ||
| Median (gday-1) | 0.05 | 0.10 | 0.13 | 0.17 | ||
| Cases/controls | 18/11719 | 13/11726 | 20/11738 | 23/11721 | ||
| Multivariate HR (95% CI) | 1 | 0.74(0.34-1.59) | 1.47(0.70-3.08) | 1.80(0.76-4.28) | ||
| 24:0 | <0.001 | 0.69(0.60-0.80) * | ||||
| Range (gday-1) | 0.00-2.60 | 2.60-3.69 | 3.69-4.82 | 4.82-9.99 | ||
| Median (gday-1) | 1.90 | 3.17 | 4.20 | 5.80 | ||
| Cases/controls | 36/11704 | 8/11737 | 13/11731 | 17/11726 | ||
| Multivariate HR (95% CI) | 1 | 0.24(0.11-0.52) * | 0.36(0.18-0.69)* | 0.42(0.22-0.81)* | ||
| Odd carbon Fatty acids (13:0,15:0,17:0) | <0.001 | 0.76(0.67-0.85) * | ||||
| Range (gday-1) | 0.00-1.65 | 1.65-3.07 | 3.07-5.85 | 5.85-10.00 | ||
| Median (gday-1) | 1.24 | 2.22 | 4.29 | 7.78 | ||
| Cases/controls | 32/11713 | 19/11725 | 15/11729 | 8/11737 | ||
| Multivariate HR (95% CI) | 1 | 0.72(0.40-1.28) | 0.49(0.26-0.91)* | 0.27(0.12-0.61)* | ||
| Long Chain fatty acids (>20C) | <0.001 | 0.71(0.61-0.82) * | ||||
| Range (gday-1) | 0.00-2.79 | 2.79-3.95 | 3.95-5.15 | 5.15-10.80 | ||
| Median (gday-1) | 2.05 | 3.41 | 4.50 | 6.18 | ||
| Cases/controls | 36/11709 | 8/11733 | 13/11730 | 17/11726 | ||
| Multivariate HR (95% CI) | 1 | 0.24(0.11-0.52) * | 0.36(0.18-0.69)* | 0.42(0.22-0.81)* | ||
| Total SFA | 0.01 | 1.05 (1.01-1.09) * | ||||
| Range (gday-1) | 1.78-30.28 | 30.28-39.22 | 39.22-47.94 | 47.94-270.28 | ||
| Median (gday-1) | 23.72 | 35.12 | 43.29 | 54.77 | ||
| Cases/controls | 19/11725 | 18/11725 | 11/11736 | 26/11718 | ||
| Multivariate HR (95% CI) | 1 | 0.95(0.46-1.96) | 0.73(0.29-1.82) | 1.63(0.56-4.75) | ||
| MUFAa: | ||||||
| 16:1 undifferentiated | 0.06 | 0.50(0.24-1.03) | ||||
| Range (gday-1) | 0.026-0.54 | 0.54-0.76 | 0.76-1.03 | 1.03-7.53 | ||
| Median (gday-1) | 0.41 | 0.65 | 0.88 | 1.28 | ||
| Cases/controls | 23/11718 | 14/11731 | 15/11730 | 22/11725 | ||
| Multivariate HR (95% CI) | 1 | 0.54(0.27-1.08) | 0.50(0.25-1.03) | 0.42(0.20-0.90)* | ||
| 18:1 undifferentiated | 0.04 | 0.92(0.85-0.99) * | ||||
| Range (gday-1) | 1.38-13.57 | 13.57-17.16 | 17.16-21.33 | 21.33-80.80 | ||
| Median (gday-1) | 11.22 | 15.39 | 19.04 | 24.89 | ||
| Cases/controls | 19/11725 | 20/11724 | 19/11727 | 16/11728 | ||
| Multivariate HR (95% CI) | 1 | 0.65(0.32-1.32) | 0.54(0.23-1.25) | 0.34(0.11-1.05) | ||
| 20:1 | 0.91 | 1.00(0.91-1.10) | ||||
| Range (gday-1) | 0.00-0.16 | 0.16-.020 | 0.20-0.29 | 0.29-9.99 | ||
| Median (gday-1) | 0.12 | 0.17 | 0.23 | 4.14 | ||
| Cases/controls | 16/11566 | 17/11575 | 21/11573 | 20/11580 | ||
| Multivariate HR (95% CI) | 1 | 0.84(0.41-1.71) | 1.39(0.69-2.79) | 1.12(0.57-2.20) | ||
| Total MUFA | 0.036 | 0.92(0.86-0.99) * | ||||
| Range (gday-1) | 1.58-14.59 | 14.59-18.46 | 18.46-22.94 | 22.94-89.58 | ||
| Median (gday-1) | 12.09 | 16.55 | 20.47 | 26.74 | ||
| Cases/controls | 19/11725 | 20/11724 | 19/11726 | 16/11729 | ||
| Multivariate HR (95% CI) | 1 | 0.68(0.34-1.36) | 0.50(0.22-1.16) | 0.32(0.10.0.99)* | ||
| PUFA n-6: | ||||||
| 20:2n-6 | 0.81 | - | ||||
| Range (gday-1) | 0.00-0.003 | 0.003-0.006 | 0.006-0.009 | 0.009-0.096 | ||
| Median (gday-1) | 0.00 | 0.00 | 0.01 | 0.01 | ||
| Cases/controls | 17/11214 | 19/12240 | 20/11671 | 18/11779 | ||
| Multivariate HR (95% CI) | 1 | 1.67(0.84-3.32) | 1.90(0.95-3.80) | 1.60(0.76-3.39) | ||
| 18:2n-6 | 0.78 | 0.97(0.83-1.14) | ||||
| Range (gday-1) | 0.00-0.79 | 0.79-1.67 | 1.67-2.66 | 2.66-37.93 | ||
| Median (gday-1) | 0.18 | 1.23 | 2.12 | 3.61 | ||
| Cases/controls | 22/11685 | 18/11762 | 19/11729 | 15/11728 | ||
| Multivariate HR (95% CI) | 1 | 1.24(0.65-2.37) | 1.26(0.66-2.41) | 0.95(0.46-1.96) | ||
| 18:2 n-6 (CLA) | 0.39 | - | ||||
| Range (gday-1) | 0.00-0.00 | 0.00-0.00 | 0.00-0.00 | 0.00-0.20 | ||
| Median (gday-1) | 0.00 | 0.00 | 0.00 | 0.01 | ||
| Cases/controls | 40/22510 | 1/928 | 14/10440 | 19/13026 | ||
| Multivariate HR (95% CI) | 1 | 0.66(0.09-4.83) | 0.94(0.50-1.75) | 0.95(0.52-1.70) | ||
| 18:2 Undifferentiated | 0.08 | 0.92(0.84-1.01) | ||||
| Range (gday-1) | 0.47-5.71 | 5.71-7.41 | 7.41-9.76 | 9.76-123.04 | ||
| Median (gday-1) | 4.68 | 6.56 | 8.39 | 12.56 | ||
| Cases/controls | 23/11721 | 22/11723 | 13/11732 | 16/11728 | ||
| Multivariate HR (95% CI) | 1 | 0.61(0.32-1.17) | 0.40(0.18-0.88)* | 0.47(0.19-1.15) | ||
| 18:3 Undifferentiated | 0.14 | 0.31(0.06-1.48) | ||||
| Range (gday-1) | 0.09-0.56 | 0.56-0.72 | 0.72-0.91 | 0.91-6.08 | ||
| Median (gday-1) | 0.46 | 0.64 | 0.80 | 1.06 | ||
| Cases/controls | 20/11715 | 18/11734 | 16/11722 | 20/11733 | ||
| Multivariate HR (95% CI) | 1 | 0.82(0.40-1.69) | 0.63(0.27-1.47) | 0.68(0.24-1.89) | ||
| 20:4 Undifferentiated | 0.73 | 0.98(0.88-1.08) | ||||
| Range (gday-1) | 0.00-0.17 | 0.17-0.25 | 0.25-0.44 | 0.44-9.99 | ||
| Median (gday-1) | 0.13 | 0.21 | 0.31 | 4.77 | ||
| Cases/controls | 23/11464 | 20/11486 | 17/11482 | 13/11486 | ||
| Multivariate HR (95% CI) | 1 | 0.87(0.47-1.59) | 0.66(0.34-1.27) | 0.38(0.18-0.78)* | ||
| PUFA n-3: | ||||||
| 20:5n-3(EPA) | 0.74 | - | ||||
| Range (gday-1) | 0.00-0.01 | 0.01-0.02 | 0.02-0.04 | 0.04-1.59 | ||
| Median (gday-1) | 0.00 | 0.01 | 0.02 | 0.06 | ||
| Cases/controls | 19/11686 | 21/11696 | 17/11791 | 17/11731 | ||
| Multivariate HR (95% CI) | 1 | 1.19(0.63-2.23) | 0.95(0.48-1.90) | 0.84(0.40-1.75) | ||
| 22:5n-3(DPA) | 0.12 | - | ||||
| Range (gday-1) | 0.00-0.01 | 0.01-0.03 | 0.03-0.05 | 0.05-0.55 | ||
| Median (gday-1) | 0.01 | 0.02 | 0.04 | 0.06 | ||
| Cases/controls | 20/11689 | 19/11744 | 17/11699 | 18/11772 | ||
| Multivariate HR (95% CI) | 1 | 1.00(0.53-1.88) | 0.95(0.49-1.84) | 0.66(0.33-1.35) | ||
| 18:3n-3(ALA) | 0.45 | 1.88(0.35-9.90) | ||||
| Range (gday-1) | 0.00-0.02 | 0.02-0.03 | 0.03-0.05 | 0.05-4.71 | ||
| Median (gday-1) | 0.02 | 0.03 | 0.04 | 0.08 | ||
| Cases/controls | 19/11712 | 14/11692 | 19/11764 | 22/11736 | ||
| Multivariate HR (95% CI) | 1 | 0.76(0.36-1.59) | 1.18(0.57-2.41) | 1.64(0.77-3.48) | ||
| 22:6n-3(DHA) | 0.28 | 0.09(0.001-7.25) | ||||
| Range (gday-1) | 0.00-0.03 | 0.03-0.06 | 0.06-0.09 | 0.09-1.62 | ||
| Median (gday-1) | 0.02 | 0.04 | 0.07 | 0.13 | ||
| Cases/controls | 20/11688 | 20/11738 | 15/11750 | 19/11728 | ||
| Multivariate HR (95% CI) | 1 | 1.05(0.56-1.97) | 0.81(0.41-1.63) | 0.69(0.34-1.39) | ||
| Total PUFAa | 0.05 | 0.91(0.84-1.00) | ||||
| Range (gday-1) | 0.66-6.67 | 6.67-8.62 | 8.62-11.29 | 11.29-125.45 | ||
| Median (gday-1) | 5.49 | 7.64 | 9.74 | 14.38 | ||
| Cases/controls | 23/11721 | 22/11722 | 11/11734 | 18/11727 | ||
| Multivariate HR (95% CI) | 1 | 0.72(0.38-1.35) | 0.24(0.10-0.57) * | 0.48(0.19-1.17) | ||
| Total n-3a | 0.52 | 0.52(0.07-3.76) | ||||
| Range (gday-1) | 0.00-0.10 | 0.10-0.16 | 0.16-0.24 | 0.24-4.90 | ||
| Median (gday-1) | 0.07 | 0.13 | 0.19 | 0.33 | ||
| Cases/controls | 17/11716 | 23/11717 | 17/11738 | 17/11733 | ||
| Multivariate HR (95% CI) | 1 | 1.42(0.75-2.69) | 1.11(0.54-2.25) | 0.70(0.32-1.53) | ||
| Total n-6a | 0.77 | 0.97(0.83-1.14) | ||||
| Range (gday-1) | 0.00-0.79 | 0.79-1.68 | 1.68-2.68 | 2.68-37.93 | ||
| Median (gday-1) | 0.19 | 1.24 | 2.12 | 3.61 | ||
| Cases/controls | 22/11721 | 18/11727 | 19/11722 | 15/11734 | ||
| Multivariate HR (95% CI) | 1 | 1.24(0.65-2.39) | 1.26(0.66-2.42) | 0.95(0.46-1.96) | ||
| Total trans | 0.05 | 1.09(0.99-1.20) | ||||
| Range (gday-1) | 0.00-4.60 | 4.60-6.56 | 6.56-8.35 | 8.35-70.12 | ||
| Median (gday-1) | 3.01 | 5.67 | 7.48 | 9.66 | ||
| Cases/controls | 20/11725 | 16/11727 | 15/11731 | 25/11721 | ||
| Multivariate HR (95% CI) | 1 | 0.89(0.43-1.83) | 1.10(0.51-2.39) | 1.92(0.84-4.41) | ||
HR (95%CI) for Cox proportional hazards regression model adjusted for energy and total fat intake, BMI, age, gender, marital status, residence, smoking, diabetes, physical activity, opium consumption, family history of cancer, ethnicity, wealth score and education
aSFA Saturated fatty acids, MUFA Mono unsaturated fatty acids, PUFA Poly unsaturated fatty acids, TFA Trans fatty acids, n-3: Omega-3 fatty acids, n-6: Omega-6 fatty acids
*Significant difference between quartiles (P<0.05)