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. 2021 Jul 6;118(28):e2026403118. doi: 10.1073/pnas.2026403118

Fig. 3.

Fig. 3.

Dexmedetomidine is a potent agonist of the OAMB receptor. (A) The screening schematic for drugs that induce follicle rupture without OA. (B) The rupture result of 18 potential stimulatory drugs from the primary screening. The black bar is a positive control of OA at 20 μM. (C and D) The dose–response analysis of abacavir (C) and dexmedetomidine (D) in inducing follicle rupture. The number of follicles used is in parentheses. (E) A schematic of the major signaling pathways involved in Drosophila follicle rupture. Dexmedetomidine is an OAMB agonist. (F and G) Dexmedetomidine-induced follicle rupture is blocked by Oamb knockdown in follicle cells. (F) The quantification of dexmedetomidine-induced follicle rupture rate using control and Oamb-knockdown mature follicles. ****P < 0.0001. (G) Representative images of mature follicles after dexmedetomidine (1 μM) treatment for 3 h. The ruptured follicles are marked with white arrowheads. All error bars are SD unless otherwise noted.