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. 2021 Jul 6;118(28):e2026403118. doi: 10.1073/pnas.2026403118

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Copyright © 2021 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

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Fig. 5. — Three out of the four drugs showed inhibition of mouse follicle rupture. (A) A schematic of mouse in vitro follicle maturation and the hCG-induced follicle rupture assay. (B) The effect of candidate drugs on hCG-induced mouse follicle rupture. ****P < 0.0001 between control and drug treatment groups. The number of follicles is listed in parentheses. (C) The influence of candidate drugs on hCG-induced progesterone production. ****P < 0.0001 between the control and Nicl group. (D) Representative images of mouse follicles treated with different drugs show successful or failed follicle rupture upon hCG stimulation.