Table 5.
Multiple Linear Regression Analysis of Δ Platelet Aggregation Rates and Δ Value of Other Clinical and Biochemical Indicators
| Variables | ΔEPI | ΔAA | ||||||
|---|---|---|---|---|---|---|---|---|
| β | t values | P values | 95% CI | β | t values | P values | 95% CI | |
| Δ Weight | 0.227 | 1.239 | 0.226 | −0.004–0.106 | 0.007 | 0.151 | 0.881 | −0.086–0.100 |
| Δ Waist | 0.000 | −0.046 | 0.964 | 0.009–0.009 | 0.004 | −0.059 | 0.953 | −0.010–0.009 |
| ΔBMI | 0.111 | 1.004 | 0.325 | −0.117–0.005 | 0.092 | 0.843 | 0.413 | −0.136–0.319 |
| ΔTCH | 0.020 | 1.320 | 0.199 | −0.011–0.051 | −0.001 | −0.073 | 0.943 | −0.039–0.036 |
| ΔTG | 0.011 | 0.991 | 0.332 | −0.012–0.035 | 0.000 | 0.099 | 0.993 | −0.026–0.026 |
| ΔLDL-C | 0.013 | 0.801 | 0.421 | −0.021–0.047 | 0.019 | 0.706 | 0.386 | −0.060–0.120 |
| ΔHDL-C | −0.029 | −0.703 | 0.489 | −0.113–0.055 | −0.004 | −1.046 | 0.306 | −0.012–0.004 |
| ΔFPG | −0.196 | −1.066 | 0.296 | −0.010–0.003 | −0.189 | −1.030 | 0.302 | −0.013–0.005 |
| ΔHbA1c | 0.091 | 0.830 | 0.415 | −0.136–0.318 | 0.085 | 0.783 | 0.321 | −0.225–0.409 |
| ΔNO | −0.194 | −2.981 | 0.032 | 0.041–0.943 | −0.252 | −4.285 | 0.000 | 0.065–0.132 |
| ΔFIB | 0.134 | 2.052 | 0.168 | 0.056–1.003 | 0.092 | 0.914 | 0.385 | 0.040–1.216 |
| ΔCD62p | 0.276 | 4.274 | 0.000 | 1.058–1.803 | 0.269 | 3.868 | 0.008 | 1.038–1.531 |
| ΔPAC-1 | 0.209 | 2.975 | 0.012 | 1.035–2.002 | 0.483 | 8.572 | 0.000 | 1.028–1.084 |
Notes: EPI model: Multiple R-squared: 0.4716, adjusted R-squared: 0.04221, AIC=−58.4923, F-statistic: 1.098; AA model: Multiple R-squared: 0.1171, adjusted R-squared: −0.6003, AIC=−44.37997, F-statistic: 0.1632. The smaller the AIC value, the better the model.
Abbreviations: Δ Weight, change in weight before and after exenatide treatment; Δ waist, change in waist before and after exenatide treatment; ΔBMI, change in body mass index before and after exenatide treatment; ΔTCH, change in total cholesterol before and after exenatide treatment; ΔTG, change in triglycerides before and after exenatide treatment; ΔLDL-C, change in low-density lipoprotein cholesterol before and after exenatide treatment; ΔHDL-C, change in high-density lipoprotein cholesterol before and after exenatide treatment; ΔFPG, change in fasting plasma glucose before and after exenatide treatment; ΔHbA1c, change in hemoglobin A1c before and after exenatide treatment; ΔNO, change in nitric oxide before and after exenatide treatment; ΔFIB, change in fibrinogen before and after exenatide treatment; ΔPAC-1, change in platelet activation complex-1 before and after exenatide treatment; ΔEPI, changes in platelet aggregation rate with epinephrine as inducer before and after exenatide treatment; ΔAA, change in platelet aggregation rate with arachidonic acid as inducer before and after exenatide treatment; CI, confidence interval.