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GSDME promotes host defense against Yptb infection. (A–I) Mice were challenged with 2 × 108 CFU Yptb. (C–H) Bacterial load in the (C and G) spleen, (D and H) liver, (E) MLNs, and (F) PP were quantified at 5 d postinfection. (C–H) Data are geometric mean pooled from two independent experiments. Survival curves are (A) representative of two experiments or pooled from (B) three or (I) two independent experiments. *P < 0.05, **P < 0.01, or ***P < 0.001.
