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. 2021 Jul 6;118(28):e2100561118. doi: 10.1073/pnas.2100561118

Fig. 1.

Fig. 1.

DNase-I affects thrombus formation and fibrin generation at the site of injury in WT mice. (A) Representative images of thrombus formation and fibrin generation after a laser injury over time in absence (NaCl) or in presence of DNase-I (DNase-I). The thrombus formation was evaluated through platelet accumulation depicted in red (X649, 0.25 µg/g of mouse). Fibrin generation was detected with Fib-DyLight 488 (0.25 µg/g of mouse) and represented in green. Blood flow was from the Top to the Bottom. (B) Graph presents kinetics of platelet accumulation after a laser injury in WT mouse in absence (NaCl, 29 thrombi in three mice) or presence of DNase-I (DNase-I, 22 thrombi in three mice). (C) Graph depicts the medians of area under curve of fluorescent signal corresponding to platelet accumulation in absence (NaCl) or presence of DNase-I (DNase-I) (Mann–Whitney U test, *P < 0.05). (D) Kinetics of fibrin accumulation after a laser injury in WT mice in absence (NaCl, 29 thrombi in three mice) or in presence of DNase-I (DNase-I, 22 thrombi in three mice). (E) Graph depicts the medians of area under curve of fluorescent signal corresponding to fibrin accumulation after a laser injury in absence (NaCl) or in presence of DNase-I (DNase-I) (Mann–Whitney U test, **P < 0.01).