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. 2021 Jul 8;118(28):e2108881118. doi: 10.1073/pnas.2108881118

Fig. 3.

Fig. 3.

Bioisosteres synthesis (A, details can be found in SI Appendix), ADME (absorption, distribution, metabolism, and excretion) data of selected drugs and their bioisosteres: sonidegib (B), boscalid (C), meclizine (D), tolvaptan (E), phthalysulfathiazole (F), lomitapide (G), and telmisartan (H). SFLOGD, shake flask log D (good range: 1 to 3) (descriptions of methods for the SFLOGD assay can be found in SI Appendix); KS, kinetic solubility (good range: >200 μM) (39); RRCK, Ralph Russ canine kidney (good range, >10) (40); HHEP, human hepatocyte stability (good range: cline <7 μL/min) (descriptions of methods for the HHEP assay can be found in SI Appendix). NMD, nonmetabolic decline. Low risk, green; moderate risk, orange; high risk, red. Note: The data for (−)-15a and (−)-15b were not provided as they are a pair of inseparable diastereomers.