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. 2021 Jul 17;11:113. doi: 10.1186/s13613-021-00899-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — sP-selectin as a marker of COVID-19 severity and a predictor of intubation and death. a Soluble P-selectin was measured in plasma from patients from COVID-19 patients from Cohort 1 and plotted according to severity grade (moderate, severe or critical disease) or from non-COVID-19 septic shock patients. Groups: mild-to-moderate (n = 35), severe (n = 10), critical (n = 15), non-COVID-19 septic shock (n = 29). *p < 0.05 (Kruskal–Wallis test followed by Dunn’s post-test). b, c, sP-selectin correlation with CRP levels (b) or platelet counts (c). r and p values were determined using Spearman’s correlation test. d, e, sP-selectin normalized to platelet counts as a predictor of intubation (d) or death (e). ROC curves with area under the curve (AUC) and associated p values are shown. Optimal threshold was determined by maximization of Youden’s index, and represented by a dashed line. Bar graphs indicate the number of patients in each group depending on normalized sP-selectin levels with respect to the optimal threshold. Groups: no intubation (n = 31), intubation (n = 29), no death (n = 43), death (n = 17)