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. 2021 Jul 17;11:113. doi: 10.1186/s13613-021-00899-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Unbiased transcriptomic analysis reveals primary hemostasis-related genes as upregulated in critically ill COVID-19 patients. RNA from patients of Cohort 2 was extracted from whole blood and RNA counts of 594 genes were determined by direct probe hybridization using the Nanostring nCounter Human Immunology v2 kit. a Gene-set enrichment analysis was performed after ranking genes according to their differential expression in severe vs critical patients. Shown are pathways significantly enriched (false discovery rate < 0.2). b Heatmap representation of genes of the primary hemostasis pathway that are upregulated in a severity grade-dependent manner (determined by hierarchical clustering). Up-regulated genes are shown in red and down-regulated genes in blue. Groups: healthy controls (n = 13), mild-to-moderate (n = 11), severe (n = 10) and critical (n = 11)