Table 2.
Cumulative incidence estimates of treatment initiation, transformation to DLBCL before treatment, and death without therapy based on the duration of W/W strategy.
Time from start of W/W | FL status | Likelihood (point estimates) in the next 1 year (95% CI) | Likelihood (point estimates) in the next 2 years (95% CI) | Likelihood (point estimates) in the next 5 years (95% CI) | Likelihood (point estimates) in the next 10 years (95% CI) |
---|---|---|---|---|---|
Diagnosis | Transformation prior to therapy | 0.01 (0.00, 0.03) | 0.03 (0.01, 0.05) | 0.06 (0.04, 0.09) | 0.09 (0.06, 0.13) |
Initiation of therapy | 0.16 (0.13, 0.20) | 0.26 (0.22, 0.31) | 0.43 (0.38, 0.48) | 0.48 (0.43, 0.54) | |
Death without therapy | 0.01 (0.00, 0.03) | 0.02 (0.01, 0.04) | 0.04 (0.03, 0.07) | 0.06 (0.04, 0.10) | |
2 years | Transformation | 0.02 (0.01, 0.04) | 0.04 (0.02, 0.07) | 0.06 (0.04, 0.10) | 0.09 (0.06, 0.14) |
Therapy | 0.10 (0.07, 0.14) | 0.18 (0.14, 0.23) | 0.30 (0.25, 0.37) | 0.39 (0.32, 0.48) | |
Death | 0.01 (0.00, 0.03) | 0.02 (0.01, 0.05) | 0.04 (0.02, 0.07) | 0.10 (0.06, 0.19) | |
4 years | Transformation | 0.02 (0.01, 0.05) | 0.03 (0.01, 0.07) | 0.05 (0.03, 0.11) | 0.09 (0.04, 0.19) |
Therapy | 0.08 (0.05, 0.14) | 0.13 (0.09, 0.19) | 0.19 (0.14, 0.26) | 0.36 (0.26, 0.50) | |
Death | 0.01 (0.00, 0.04) | 0.02 (0.01, 0.05) | 0.02 (0.02, 0.06) | 0.17 (0.09, 0.33) | |
5 years | Transformation | 0.01 (0.00, 0.05) | 0.02 (0.01, 0.06) | 0.06 (0.02, 0.13) | 0.08 (0.04, 0.20) |
Therapy | 0.05 (0.03, 0.10) | 0.09 (0.05, 0.16) | 0.12 (0.07, 0.19) | 0.31 (0.20, 0.47) | |
Death | 0.01 (0.00, 0.05) | 0.01 (0.00, 0.06) | 0.04 (0.02, 0.11) | 0.18 (0.09, 0.37) | |
6 years | Transformation | 0.01 (0.00, 0.06) | 0.02 (0.00, 0.07) | 0.05 (0.02, 0.12) | 0.08 (0.03, 0.21) |
Therapy | 0.04 (0.02, 0.10) | 0.07 (0.04, 0.14) | 0.13 (0.07, 0.23) | 0.28 (0.17, 0.45) | |
Death | 0.02 (0.00, 0.06) | 0.02 (0.00, 0.05) | 0.06 (0.02, 0.16) | 0.19 (0.09, 0.39) |