Table 2.
Genes related to a number of ligands (top) and receptors (bottom) expressed to different degrees in AVPV Kiss1 cells
| LIGANDSENSEMBL ID | ENTREZ ID | Gene | Overall Mean expression |
Mean E2 expression | Mean OVX expression | Log FC | Adjusted p value |
|---|---|---|---|---|---|---|---|
| ENSMUSG00000045573 | 18 619 | Penk | 10.164 | 10.405 | 9.984 | -0.422 | 0.057 |
| ENSMUSG00000037428 | 381 677 | Vgf | 9.928 | 10.307 | 9.644 | -0.664 | 0.001 |
| ENSMUSG00000026787 | 14 417 | Gad2 | 9.757 | 10.01 | 9.566 | -0.445 | 0.003 |
| ENSMUSG00000070880 | 14 415 | Gad1 | 9.460 | 9.519 | 9.417 | 0.102 | 0.351 |
| ENSMUSG00000037771 | 22 348 | Vgat | 8.640 | 8.673 | 8.716 | -0.076 | 0.655 |
| ENSMUSG00000000214 | 21 823 | Th | 8.655 | 9.177 | 8.263 | -0.915 | <0.001 |
| ENSMUSG00000116158 | 280 287 | Kiss1 | 7.192 | 8.759 | 6.016 | -2.734 | <0.001 |
| ENSMUSG00000024907 | 14 419 | Gal | 8.287 | 8.686 | 7.987 | -0.701 | 0.020 |
| ENSMUSG00000021647 | 27 220 | Cartpt | 7.372 | 8.104 | 6.823 | 1.278 | <0.001 |
| ENSMUSG00000029361 | 18 125 | Nos1 | 7.314 | 7.538 | 7.145 | -0.393 | 0.010 |
| ENSMUSG00000027400 | 18 610 | Pdyn | 7.207 | 6.824 | 7.494 | 0.669 | 0.022 |
| ENSMUSG00000045731 | 18 155 | Pnoc | 6.652 | 6.970 | 6.414 | -0.556 | 0.025 |
| ENSMUSG00000031980 | 11 606 | Agt | 6.311 | 5.922 | 6.603 | 0.687 | 0.059 |
| ENSMUSG00000030500 | 140 919 | Vglut2 | 5.762 | 5.840 | 5.704 | -0.140 | 0.537 |
| ENSMUSG00000005892 | 22 044 | Trh | 5.285 | 5.220 | 5.333 | 0.106 | 0.838 |
| ENSMUSG00000049796 | 12 918 | Crh | 5.075 | 5.023 | 5.115 | 0.086 | 0.905 |
| ENSMUSG00000061762 | 21 333 | Tac1 | 4.554 | 4.313 | 4.735 | 0.432 | 0.229 |
| ENSMUSG00000024256 | 11 516 | Adcyap1 | 4.147 | 4.459 | 3.913 | -0.557 | 0.152 |
| ENSMUSG00000029236 | 56 183 | Nmu | 4.132 | 4.145 | 4.121 | -0.032 | 0.926 |
| ENSMUSG00000032532 | 12 424 | Cck | 3.495 | 4.005 | 3.112 | -0.902 | 0.157 |
| RECEPTORSENSEMBL ID | ENTREZ ID | Gene | OverallMean Expression | Mean E 2 expression | Mean OVXexpression | Log FC | Adjusted P value |
| ENSMUSG00000058756 | 21 833 | Thra | 9.075 | 8.895 | 9.210 | 0.314 | 0.143 |
| ENSMUSG00000029778 | 11 517 | Pacapr1 | 8.478 | 8.358 | 8.569 | 0.211 | 0.163 |
| ENSMUSG00000019768 | 13 982 | Esr1 | 7.884 | 7.672 | 8.044 | 0.372 | 0.105 |
| ENSMUSG00000027584 | 18 389 | Oprl1 | 7.176 | 7.086 | 7.244 | 0.157 | 0.303 |
| ENSMUSG00000024431 | 14 815 | Nr3c1 | 6.542 | 6.296 | 6.726 | 0.430 | 0.056 |
| ENSMUSG00000005268 | 19 116 | Prlr | 6.476 | 6.883 | 6.171 | -0.714 | 0.011 |
| ENSMUSG00000044288 | 12 801 | Cnr1 | 6.408 | 6.092 | 6.645 | 0.554 | 0.023 |
| ENSMUSG00000046532 | 11 835 | Ar | 6.279 | 6.394 | 6.192 | -0.205 | 0.366 |
| ENSMUSG00000039059 | 99 296 | Hrh3 | 6.180 | 6.350 | 6.052 | -0.301 | 0.243 |
| ENSMUSG00000025905 | 18 387 | Oprk1 | 6.022 | 5.874 | 6.133 | 0.254 | 0.215 |
| ENSMUSG00000028004 | 18 167 | Npy2r | 5.908 | 4.206 | 7.185 | 2.976 | <0.001 |
| ENSMUSG00000031870 | 18 667 | Pgr | 5.759 | 6.936 | 4.875 | -2.064 | <0.001 |
| ENSMUSG00000021779 | 21 834 | Thrb | 4.223 | 4.296 | 4.169 | -0.132 | 0.655 |
| ENSMUSG00000055737 | 146 00 | Ghr | 4.046 | 4.068 | 4.030 | -0.044 | 0.895 |
| ENSMUSG00000036437 | 18 166 | Npy1r | 4.031 | 4.360 | 3.785 | -0.595 | 0.117 |
| ENSMUSG00000030043 | 21 336 | Tacr1 | 3.847 | 3.731 | 3.934 | 0.201 | 0.485 |
| ENSMUSG00000044014 | 18 168 | Npy5r | 3.524 | 2.967 | 3.942 | 0.964 | 0.029 |
| ENSMUSG00000047259 | 17 202 | Mc4r | 3.363 | 3.537 | 3.232 | -.0318 | 0.496 |
| ENSMUSG00000018634 | 12 921 | Crhr1 | 3.067 | 2.796 | 3.270 | 0.480 | 0.289 |
| ENSMUSG00000011171 | 22 355 | Vipr2 | 3.032 | 2.912 | 3.122 | 0.208 | 0.640 |
| ENSMUSG00000020123 | 54 140 | Avpr1a | 1.919 | 1.440 | 2.277 | 0.845 | 0.136 |
| ENSMUSG00000021055 | 13 983 | Esr2 | 1.379 | 1.358 | 1.395 | 0.033 | 0.971 |
| ENSMUSG00000048337 | 19 065 | Npy4r | 0.130 | 2.620 | -1.740 | -4.360 | < 0.001 |
Transcripts are listed in descending order of overall mean expression (mean logCPM from all samples, regardless of hormonal condition). P-values < 0.05 denote significantly different expression between OVX and E2 conditions.