Table 3.
Optimization of Loading Capacity and Encapsulation rate.The Loading Efficiency and Encapsulation Rate of GO-PEG Were Detected by HPLC, and Different Proportions of GO-PEG and OH30 Were Mixed to Obtain Better Loading Efficiency and Encapsulation Rate (Mean ± SD, n =3)
| Ratio of OH30 and GO-PEG | Loading Efficiency(%) | Encapsulation Efficiency (%) |
|---|---|---|
| 0.1mg/ml GO-PEG+0.4mg/ml OH30 | 55.15±3.30 | 30.71±3.64 |
| 0.1mg/ml GO-PEG+0.6mg/ml OH30 | 61.69±0.99 | 26.87±1.15 |
| 0.1mg/ml GO-PEG+1mg/ml OH30 | 69.56±0.93 | 22.89±0.99 |
| 0.1mg/ml GO-PEG+2mg/ml OH30 | 80.83±1.15 | 20.47±2.45 |
| 0.1mg/ml GO-PEG+2.5mg/ml OH30 | 79.88±0.11 | 13.0±0.31 |
Abbreviations: GO-PEG, PEGylated graphite oxide; OH30, OH-CATH30.