. 2021 Jul 13;14:3185–3196. doi: 10.2147/JIR.S319213

Table 2.

Significant Factors Associated with GSDMD, IL-1ß and IL-18 by Step Forward Multiple Linear Regression Analysis in Liver Cirrhosis Patients

Variables	GSDMD				IL-1ß				IL-18
Variables	Univariate*		Multivariate⁺		Univariate*		Multivariate⁺		Univariate*		Multivariate⁺
	ß	p value	ß	p value	ß	p value	ß	p value	ß	p value	ß	p value
Age (Years)	−0.492	0.059			−1.049	0.283			−1.852	0.32
Gender
Male^a
Female	−1.649	0.768			−22.072	0.517			−40.429	0.375
Aetiology
Viral hepatitis^a
Alcohol	15.151	0.084			−95.263	0.069			−189.248	0.006	65.041	0.001
Autoimmune	−20.27	0.013	0.069	0.191	−157.97	< 0.001	−49.842	0.008	−292.305	< 0.001	−240.457	0.002
AST (U/L)	0.042	0.003	0.008	0.883	0.231	0.006	0.146	0.066	0.288	0.008	0.096	0.205
PLT	−0.019	0.672			0.158	0.561			0.155	0.67
APRI score	3.048	< 0.001	−0.016	0.774	14.225	0.003	0.117	0.16	16.228	0.012	0.020	0.800
Child-Pugh classification	31.33	< 0.001	31.343	<0.001	78.197	< 0.001	59.919	0.003	118.197	< 0.001	101.793	< 0.001
Compensated status	7.707	0.178			132.87	< 0.001	0.116	0.197	191.081	< 0.001	0.133	0.13

Notes: a, reference group; ß, regression coefficient; *, univariate coefficients; ⁺, a stepwise multivariate regression analysis was performed; APRI: AST to Platelet Ratio Index. p value < 0.05 was considered statistically significant.