TABLE 2.

The roles of m⁶A regulators in human cancer

Cancer types	Regulators	Target genes	Roles	References
Liver cancer	METTL3	SOCS2, SNAIL, LINC00958	Oncogene	[64, 214, 215]
	METTL14	pri‐miR‐126	Tumor suppressor	[62]
	WTAP	ETS1	Oncogene	[65]
	VIRMA	ID2, GATA3	Oncogene	[66, 67]
	ALKBH5	LYPD1	Tumor suppressor	[68]
	FTO	GNAO1	Tumor suppressor	[69]
	YTHDF1		Oncogene	[63, 73]
	YTHDF2	EGFR, IL11, SRPINE2	Controversial	[70, 71, 72]
	IGF2BP1/2/3	MYC, FSCN1, TK1, MARCRSL1	Oncogene	[29]
	IGF2BP1	SRF	Oncogene	[74]
Non‐small Cell Lung Carcinoma	METTL3	YAP, MALAT1, EGFR, TAZ, BRD4	Oncogene	[41, 42, 120]
	FTO	MZF1, USP7	Oncogene	[121, 122]
	ALKBH5	UBE2C, FOXM1, YAP	Oncogene	[123, 124, 125]
	YTHDF1	KEAP1	Oncogene	[126]
	YTHDF2	6PGD	Oncogene	[127]
Gastric Cancer	METTL3	ZMYM1, HDGF, SEC62, ARHGAP5‐AS1	Oncogene	[76, 77, 78, 79, 80, 81]
	METTL14		Tumor suppressor	[82]
	FTO		Oncogene	[82]
	ALKBH5	NEAT1	Oncogene	[83]
	YTHDF2		Oncogene	[216]
	IGF2BP3	HDGF	Oncogene	[77]
Colorectal Cancer	METTL3	SOX2, pri‐miR‐1246	Oncogene	[97, 98]
	METTL14	pri‐miR‐375, lncRNA XIST, SOX4	Tumor suppressor	[94, 95, 96]
	YTHDF1		Oncogene	[99, 100]
	YTHDF3	GAS5 lncRNA	Oncogene	[101]
	IGF2BP2	SOX2, MYC	Oncogene	[98, 102]
Glioblastoma	METTL3	ADAM19, SRSFs, SOX2	Controversial	[105, 106, 107]
	METTL14	ADAM19	Tumor suppressor	[107]
	FTO		Oncogene	[107]
	ALKBH5	FOXM1	Oncogene	[108]
	YTHDF2	MYC, VEGFA	Oncogene	[109]
Acute Myeloid Leukemia	METTL3	MYC, BCL2, PTEN, SP1, SP2	Oncogene	[57, 58]
	METTL14	MYB, MYC	Oncogene	[59]
	FTO	ASB2, RARA, MYC, CEBPA	Oncogene	[51, 52]
	ALKBH5	AXL, TACC3	Oncogene	[55, 56]
	YTHDF2	TNFRSF2	Oncogene	[60]
Pancreatic Cancer	METTL3	pri‐miR‐25	Oncogene	[90, 91, 152]
	FTO	MYC	Oncogene	[89]
	ALKBH5	KCNK15‐AS1, WIF1, PER1	Tumor suppressor	[86, 87, 88]
	YTHDF2	YAP	Oncogene	[92]
	IGF2BP2	DANCR	Oncogene	[93]
Breast Cancer	METTL3	HBXIP, BCL2, AK4	Oncogene	[111, 217, 218]
	METTL14	transforming growth factor β signaling pathway genes	Oncogene	[113]
	FTO	BNIP3, miR‐181b‐3p	Oncogene	[117, 118]
	ALKBH5	NANOG	Oncogene	[114‐116, 219]
	YTHDF3	ST6GALNAC5, GJA1, EGFR	Oncogene	[119]