Table 2.

Univariate and Multivariate Analyses of Clinicopathological Features and the microRNA-Based Risk Score

Characteristic		Univariate Cox Analysis			Multivariate Cox Analysis
		Beta	HR	P value	Beta	HR	P value
Sex	Male	Ref.
	Female	0.179	1.196	0.331
Age	< 65 yr	Ref.
	≥ 65 yr	0.189	1.209	0.289
T	T1-2	Ref.
	T3-4	0.922	2.514	<0.001	1.106	3.021	0.038
	Tx/Not available	0.432	1.541	0.668	0.258	1.295	0.811
N	N0	Ref.
	N1	0.762	2.143	0.289	1.025	2.787	0.186
	Nx/Not available	0.434	1.543	0.023	0.360	1.433	0.211
M	M0	Ref.
	M1	1.436	4.203	0.015	1.125	3.080	0.069
	Mx/Not available	0.435	1.545	0.026	0.267	1.306	0.363
AJCC stage	I–II	Ref.
	III–IV	0.897	2.451	<0.001	−0.388	0.678	0.499
	Not available	0.925	2.523	0.002	−0.170	0.844	0.691
Grade	G1-2	Ref.
	G3-4	0.046	1.047	0.803
	Not available	0.462	1.586	0.434
AFP (ng/mL)	<20
	≥20	0.551	1.734	0.014	0.278	1.321	0.241
	Not available	1.177	3.243	<0.001	0.769	2.157	0.002
Vascular invasion	None	Ref.
	Macro	0.714	2.042	0.060	0.138	1.148	0.734
	Micro	0.234	1.264	0.311	0.107	1.113	0.663
	Not available	0.993	2.699	<0.001	0.525	1.690	0.032
Risk score		1.000	2.718	<0.001	1.039	2.827	<0.001

Abbreviations: HR, hazard rate; Ref., reference; AJCC, American Joint Committee on Cancer; AFP, alpha- fetoprotein.