Table 4.

Association of Presence of Cirrhosis With All-Cause 30-Day Mortality in All Patients With Chronic Liver Disease Who Tested Positive for SARS-CoV-2 Infection (Cirrhosis/Positive vs Noncirrhosis/Positive)

Variable	Univariable Cox regression			Multivariable Cox regression
	HR	95% CI	P value	aHR	95% CI	P value
Presence of cirrhosis	5.34	4.75–6.00	<.01	3.31	2.91–3.77	<.01
Age, y	1.07	1.06–1.07	<.01	1.05	1.05–1.06	<.01
Sex, female	0.65	0.58–0.73	<.01	0.84	0.74–0.95	<.01
Race/ethnicity
White	Ref	—	—	Ref	—	—
Black/African American	1.29	1.11–1.49	<.01	0.98	0.83–1.15	.80
Hispanic	0.95	0.81–1.2	.54	1.20	1.02–1.42	.03
Asian	1.11	0.81–1.54	.51	1.38	0.99–1.92	.06
Unknown/other	1.04	0.84–1.29	.69	1.25	1.01–1.55	.04
Etiology of liver disease
NAFLD	Ref	—	—	Ref	—	—
Hepatitis C	1.86	1.61–2.16	<.01	1.27	1.08–1.48	<.01
AALD	2.55	2.20–2.96	<.01	1.40	1.20–1.65	<.01
Hepatitis B	1.44	1.08–1.91	.01	0.93	0.70–1.25	.65
Cholestatic	1.95	1.34–2.85	<.01	0.74	0.51–1.09	.13
Autoimmune	2.00	1.38–2.91	<.01	1.19	0.82–1.73	.37
Modified CCIa	1.18	1.16–1.19	<.01	1.07	1.05–1.08	<.01
Region
Northeast	Ref	—	—	Ref	—	—
Midwest	0.49	0.40–0.59	<.01	0.51	0.41–0.62	<.01
South	0.65	0.53–0.78	<.01	0.75	0.61–0.91	<.01
West	0.30	0.23–0.40	<.01	0.43	0.33–0.57	<.01
Other	0.40	0.34–0.47	<.01	0.46	0.39–0.54	<.01

^aModified CCI was calculated based on the original CCI score, excluding weights for “mild liver disease” and “severe liver disease.”