Table 6.
Association of SARS-Cov-2 Infection With All-Cause 30-Day Mortality in Patients With Cirrhosis (Cirrhosis/Positive vs Cirrhosis/Negative) Stratified by Age, Body Mass Index, MELD-Na Score, and Selected Comorbidities
| Cirrhosis/positive vs cirrhosis/negative | Cirrhosis/ negative, n (%) | Death at 30d, cumulative incidence rate, % (95% CI) | Cirrhosis/ positive, n (%) | Death at 30d, cumulative incidence rate, % (95% CI) | aHR (95% CI) | P value |
|---|---|---|---|---|---|---|
| All patients | 53,476 (100) | 3.9 (3.7–4.0) | 8941 (100) | 8.9 (8.3–9.5) | 2.38 (2.18–2.59) | <.01 |
| Compensated | 16,546 (31) | 0.9 (0.8–1.1) | 2948 (33) | 4.7 (3.9–5.5) | 5.00 (3.92–6.37) | <.01 |
| Decompensated | 36,930 (69) | 5.2 (4.9–5.4) | 5993 (67) | 11.0 (10.1–11.8) | 2.20 (2.01–2.41) | <.01 |
| Stratified by agea | ||||||
| 18–29 y | 1431 (3) | 2.0 (1.2–2.7) | 229 (3) | 3.7 (1.1–6.1) | 1.84 (0.81–4.16) | .14 |
| 30–49 y | 11,315 (21) | 3.2 (2.9–3.5) | 1696 (19) | 4.8 (3.7–5.9) | 1.59 (1.23–2.05) | <.01 |
| 50–64 y | 22,528 (42) | 3.8 (3.6–4.1) | 3702 (41) | 7.6 (6.7–8.4) | 2.05 (1.78–2.35) | <.01 |
| 65 y or older | 18,202 (34) | 4.4 (3.1–4.7) | 3314 (37) | 12.9 (11.7–14.1) | 3.03 (2.68–3.42) | <.01 |
| Stratified by BMI | ||||||
| No BMI data | 18,096 (34) | 3.9 (3.6–4.1) | 4197 (47) | 8.4 (7.5–9.3) | 2.23 (1.95–2.55) | <.01 |
| BMI available | 35,380 (66) | 3.9 (3.7–4.1) | 4744 (53) | 9.4 (8.5–10.2) | 2.40 (2.15–2.68) | <.01 |
| BMI <25 kg/m2 | 10,143 (19) | 4.5 (4.1–4.9) | 1107 (12) | 10.5 (8.6–12.4) | 2.11 (1.70–2.62) | <.01 |
| BMI 25–30 kg/m2 | 10,039 (19) | 3.8 (3.4–4.2) | 1236 (14) | 8.8 (7.1–10.4) | 2.30 (1.84–2.87) | <.01 |
| BMI 30–35 kg/m2 | 7429 (14) | 3.5 (3.1–3.9) | 1048 (12) | 8.7 (7.0–10.5) | 2.51 (1.96–3.22) | <.01 |
| BMI ≥35 kg/m2 | 7769 (15) | 3.5 (3.1–4.0) | 1353 (15) | 9.5 (7.9–11.1) | 2.74 (2.21–3.40) | <.01 |
| Stratified by MELD-Na | ||||||
| No MELD-Na data | 44,096 (82) | 2.6 (2.4–2.7) | 7534 (84) | 6.9 (6.3–7.4) | 2.75 (2.47–3.07) | <.01 |
| MELD-Na available | 9380 (18) | 9.9 (9.3–10.5) | 1407 (16) | 19.6 (17.4–21.7) | 2.06 (1.79–2.38) | <.01 |
| MELD-Na 6–15 | 4257 (8) | 1.8 (1.4–2.2) | 581 (6) | 6.8 (4.7–8.9) | 3.49 (2.32–5.23) | <.01 |
| MELD-Na 15–20 | 1726 (3) | 4.1 (3.1–5.0) | 284 (3) | 13.3 (9.1–17.2) | 2.91 (1.92–4.42) | <.01 |
| MELD-Na 20–25 | 1298 (2) | 9.6 (8.0–11.2) | 233 (3) | 22.4 (16.7–27.7) | 2.27 (1.61–3.18) | <.01 |
| MELD-Na 25–30 | 827 (2) | 20.0 (17.2–22.8) | 129 (1) | 34.3 (25.2–42.4) | 1.68 (1.18–2.40) | <.01 |
| MELD-Na 30–35 | 451 (1) | 34.7 (30.0–39.2) | 62 (1) | 49.9 (34.7–61.6) | 1.44 (0.94–2.20) | .09 |
| MELD-Na na ≥35 | 821 (2) | 41.8 (38.2–45.2) | 118 (1) | 61.1 (50.7–69.3) | 1.36 (1.03–1.79) | .03 |
| Stratified by modified CCIb | ||||||
| Modified CCI 0 | 13,728 (26) | 3.6 (3.2–3.9) | 1936 (22) | 7.2 (6.0–8.5) | 2.08 (1.70–2.55) | <.01 |
| Modified CCI 1–2 | 15,357 (29) | 3.2 (2.9–3.5) | 2441 (27) | 7.7 (6.6–8.8) | 2.57 (2.15–3.06) | <.01 |
| Modified CCI 3–4 | 9291 (17) | 3.5 (3.1–3.9) | 1550 (17) | 8.4 (7.0–9.8) | 2.54 (2.06–3.14) | <.01 |
| Modified CCI ≥5 | 15,100 (28) | 5.0 (4.6–5.3) | 3014 (34) | 11.2 (10.0–12.4) | 2.37 (2.08–2.71) | <.01 |
| Stratified by comorbidities | ||||||
| No diabetes | 32,522 (61) | 3.9 (3.7–4.1) | 4602 (51) | 8.5 (7.6–9.3) | 2.28 (2.02–2.56) | <.01 |
| Diabetes | 20,954 (39) | 3.8 (3.6–4.1) | 4339 (49) | 9.4 (8.5–10.3) | 2.58 (2.28–2.92) | <.01 |
| No renal disease | 43,241 (81) | 3.5 (3.3–3.6) | 6713 (75) | 7.9 (7.2–8.6) | 2.39 (2.15–2.65) | <.01 |
| Renal disease | 10,235 (19) | 5.5 (5.1–6.0) | 2228 (25) | 12.0 (10.6–13.4) | 2.30 (1.98–2.67) | <.01 |
| No heart failure | 43,241 (81) | 3.5 (3.3–3.7) | 6897 (77) | 7.9 (7.2–8.5) | 2.34 (2.12–2.60) | <.01 |
| Heart failure | 10,235 (19) | 5.4 (4.9–5.8) | 2044 (23) | 12.5 (11.0–13.9) | 2.45 (2.10–2.85) | <.01 |
| No pulmonary disease | 37,205 (70) | 3.9 (3.7–4.1) | 6082 (68) | 8.5 (7.8–9.3) | 2.27 (2.04–2.52) | <.01 |
| Pulmonary disease | 16,271 (30) | 3.8 (3.5–4.1) | 2859 (32) | 9.7 (8.6–10.8) | 2.63 (2.27–3.05) | <.01 |
NOTE. Categorical variables are presented as n (%). Unless otherwise noted, aHRs are reported from multivariable model adjusting for age, sex, race/ethnicity, etiology of liver disease, modified CCI, and region.
Adjusted HRs for stratified age group analyses are reported from multivariable model adjusting for sex, race/ethnicity, etiology of liver disease, modified CCI, and region.
Modified CCI was calculated based on the original CCI score, excluding weights for “mild liver disease” and “severe liver disease.” Adjusted HRs are reported from multivariable model adjusting for age, sex, race/ethnicity, etiology of liver disease, and region.