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. 2021 Jul 12;14:883–896. doi: 10.2147/JAA.S312361

Figure 1.

Figure 1

Large- and small-airway obstruction in mice representing different airway inflammation models. Airway function in mice was measured using a forced manoeuvres system. (A) FVC showed no difference between the control group and asthma models. (B–D, H) Large-airway function (FEV25, FEV50, FEV75, FEF25) in mice. (E–G) Small-airway function (FEF50, FEF75, MMEF) declined in mouse models of asthma. *P < 0.05, **P < 0.01, ***P < 0.001.

Abbreviations: FVC, forced vital capacity; FEF75, forced expiratory flow at 75% of FVC (25% expired); FEF50, forced expiratory flow at 50% of FVC; FEF25, forced expiratory flow at 25% of FVC (75% expired); FEV25, volume expired in the first 25 ms of fast expiration; FEV50, volume expired in the first 50 ms of fast expiration; FEV75, volume expired in first 75 ms of fast expiration; MMEF, mean mid expiratory flow, average flow from 25–75% FVC.