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. 2021 Jul 17;12(8):716. doi: 10.1038/s41419-021-04007-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Statistics for the amplitude of K⁺-current (I_K) measured at 30 mV (upper bars) and 80 mV (lower bars) in isogenic control (wt tau) and MAPT IVS10+16 neurons. Boxes show median values; ***p < 0.001 (nonparametric Mann–Whitney test). The number of tested cells indicated. B. I–V relationship for the I_K density in the isogenic control (wt tau) and the MAPT IVS10+16 cohorts. C. Conductance–voltage relationships of I_K recorded in wt tau and MAPT IVS10+16 neurons. Conductance was normalized to the maximal I_K conductance; lines are Boltzmann fitting.