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. 2021 Jul 17;12(8):716. doi: 10.1038/s41419-021-04007-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Example recordings of action potentials (AP) in a control (wild type, wt, tau) iPSC-derived neuron (left) and a MAPT IVS10+16 neuron (right) elicited by square depolarizing current pulses (indicated on the bottom). B–D Statistics for the AP amplitude (B), the threshold (C) and the width measured at half-maximal amplitude in control (wt tau) and MAPT IVS10+16 neurons. Analysis performed for the first AP spike. Data are mean ± s.e.m. ***P < 0.001, p = 0.031 for (C), and p = 0.039 for (D) (the two-tailed unpaired t-test). Number of cells, n = 9 per group.