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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Semin Cancer Biol. 2021 Jan 18;82:120–133. doi: 10.1016/j.semcancer.2020.12.016

Fig. 8. LRIG1 as a pleiotropic feedback tumor suppressor.

Fig. 8.

(A) In PCa, oncogenic signaling from androgen/AR, ERBB/ligands and MYC induces LRIG1 expression and the upregulated LRIG1, in turn, antagonizes tumorigenesis driven by these pathways. Adapted with permission from [100]. (B) LRIG1 similarly functions as a feedback tumor suppressor in other ERBB-driven human cancers (see Text).