Fig. 2.

The tumor vasculature remodels throughout E0771 disease progression. Representative images (a) and quantification of mean vascular volume (b), vascular surface area (c), and vessel diameter (d) of micro-computed tomography 3D reconstructions of the mammary fatpad or E0771 tumors. VEGF-A (e) and VEGF-C (f) levels in the naïve or tumor-bearing mammary fatpad throughout disease progression. *Significance by two-way ANOVA with Tukey comparison; ^#Significance against theoretical value of 1.0 by one-sample t test; n = 5–6 mice; scale bar indicates 1 mm