Fig. 4.

Molecular dissemination from breast tumors is altered by E0771 disease and progression. a Vascular and lymphatic remodeling of the TME may impact molecular dissemination into systemic tissues versus dLN. b Tracer accumulation within systemic tissues (spleen, liver, and kidneys) of naïve (N) and d 7, 14, and 21 tumor-bearing animals over 72 h post-injection as quantified as concentration AUC. c Relative change in levels of tracer accumulation within the dLN and NdLN over 72 h post-injection quantified as % injection AUC. *Significance relative to naïve, $ indicates significance relative to d7, and ^{^}significance relative to d14 by two-way ANOVA with Tukey’s post hoc test; ^#significance relative to theoretical value of 1.0 by one-sample t test; n = 5–6 mice