Fig. 5.

E0771 disease progression effects on accumulation of intra-fatpad injected tracers within inguinal and axillary LNs. Levels of tracer accumulation within the inguinal (1°) (a) and axillary (2°) (b) draining and NdLNs over 72 h post-injection during tumor development quantified as % injection AUC. (c) Fold change in tracer accumulation within TdLNs over 72 h post-injection in the mammary fatpad (% injection AUC) relative to naïve animals. *Significance relative to naïve by two-way ANOVA with Tukey comparison; ^#significance relative to theoretical value of 1.0 using one-sample t test; n = 5–6 mice