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. Author manuscript; available in PMC: 2022 Jan 15.
Published in final edited form as: Cancer Res. 2021 Mar 9;81(14):3905–3915. doi: 10.1158/0008-5472.CAN-21-0033

Figure 7. Hypothermia cooperates with chemotherapy to induce regression of tumors expressing ts p53.

Figure 7.

(A) Nude mice with subcutaneous GA10 and GA10-p53KO tumors were treated with combination of CPT and 32°C hypothermia in 32 hr × 5 format. CPT (1.5 mg/kg) was given at the beginning of each hypothermia cycle. Average size of tumors was plotted over time (mean ± SD). (B) Pictures of a GA10 partial response tumor before and after treatment. (C) Waterfall plot showing combined results of 3 experiments. Tumors with durable remission are marked as “cured”. (D) Individual growth curves of representative GA10 tumors from (A) that achieved durable remission after treatment. (E) Individual growth curves of GA10 tumors from (A) that relapsed and received re-treatment.