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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2021 Mar 26;110(5):1519–1529. doi: 10.1016/j.ijrobp.2021.03.039

Figure 3. Influence of oxygen-breathing on tumor growth delay.

Figure 3

A) Kaplan Meier plots of the surviving fractions with respect to inhaled gas. Unirradiated tumors (blue) had a volume quadrupling time (VQT) = 11 days. A dose of 40 Gy caused significant tumor growth delay for air breathing rats (black; VQT = 48 days; p=0.0002) with about 10% of tumors controlled at 200 days. When 40 Gy irradiation was accompanied with oxygen breathing (red), the growth delay was increased further: VQT = 74 days for tumors, which progressed, while 3 of 8 showed control; p=0.0201 vs. air and p=0.0002 vs. unirradiated).

B) Growth curves for subcutaneous AT1 tumors following focal irradiation with 40 Gy when rats breathed either oxygen or air. Oxygen breathing (red) generally enhanced the tumor growth delay compared to the air-breathing animals (black), but there was obvious overlap. Most tumors continued to grow for about 10 days following irradiation before shrinking.