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. Author manuscript; available in PMC: 2022 Jul 15.
Published in final edited form as: Mol Cell. 2021 Jun 8;81(14):3007–3017.e5. doi: 10.1016/j.molcel.2021.05.014

Figure 5. RADX inactivation suppresses fork reversal in cells experiencing persistent replication stress.

Figure 5.

(A) Example of a reversed fork observed by EM (Inset, magnified four-way junction at the reversed fork; P, parental strands; D, daughter strands; R, reversed strands). (B) Quantitation of fork reversal measured by EM in the indicated U2OS cells treated with 3mM HU for 5h (n=3; Mean +/− SEM). The number of replication intermediates analyzed for each condition is indicated in parenthesis. P values were calculated using a Welch test. See also Table S1 and Figure S2.