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. Author manuscript; available in PMC: 2022 Jul 16.
Published in final edited form as: ACS Chem Biol. 2021 Jun 30;16(7):1234–1242. doi: 10.1021/acschembio.1c00279

Figure 5.

Figure 5.

(A) and (B) IC50 curves of compound 1 (NAH-C3-GPKK) and sinefungin for HemK2/KMT9-Trm112 activity on a GGQ peptide (n=3). The concentration of the HemK2/KMT9-Trm112 complex was 0.6 μM; (C) and (D) IC50 curves of compound 1 (NAH-C3-GPKK) and sinefungin for HemK2/KMT9-Trm112 activity on a GGQ peptide (n=3). The concentration of the complex was 10 μM; (E) compound 1 (NAH-C3-GPKK) for MettL5-Trm112 activity (n=3). The concentration of the complex was 0.2 μM.