Table 3:
Summary of HLA Alleles with Potential Association with Allopurinol Hepatotoxicity
| Cases & controls: | Allopurinol cases | BioMe controls | DILIN controls | ||||
|---|---|---|---|---|---|---|---|
| All subjects | Sample sizes | n=11 | n=8,780 | n=1,512 | |||
| HLA allele | AF | count | AF | p value: Cases vs BioMe AF | AF | p value: Cases vs DILIN AF | |
| A*34:02 | 0.182 | 4 | 0.023 | 0.001 | 0.010 | 8.22E-05 | |
| B*53:01 | 0.227 | 5 | 0.085 | 0.035 | 0.026 | 0.0002 | |
| B*58:01 | 0.182 | 4 | 0.036 | 0.008 | 0.016 | 0.0005 | |
| African Americans | Sample size | n=7 | n=5,816 | n=177 | |||
| HLA allele | AF | count | AF | p value: Cases vs BioMe AF | AF | p value: Cases vs DILIN AF | |
| A*34:02 | 0.214 | 3 | 0.033 | 0.010 | 0.057 | 0.050 | |
| B*53:01 | 0.357 | 5 | 0.120 | 0.020 | 0.184 | 0.155 | |
| B*58:01 | 0.214 | 3 | 0.046 | 0.024 | 0.020 | 0.005 | |
Note: p-values were from Fisher exact tests to compare allopurinol Cases to BioMe controls and to DILIN controls