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. 2021 Jun;25(6):668–674. doi: 10.5005/jp-journals-10071-23827

Table 1.

Differential diagnosis of various radiological patterns in HAPE (only common causes enumerated with most important differentials listed first)

Bilateral symmetrical perihilar opacities Bilateral symmetrical diffuse opacities Unilateral diffuse opacities Bilateral asymmetrical focal opacities Lobar consolidation
Cardiogenic
pulmonary edema
Diffuse alveolar
hemorrhage
ARDS
Viral pneumonia
PJP
Acute interstitial
pneumonia
Acute eosinophilic
pneumonia
ARDS
Diffuse alveolar
hemorrhage
Viral pneumonia
PJP
Cardiogenic edema
Acute hypersensitivity pneumonitis
Acute interstitial
pneumonia
Acute eosinophilic
pneumonia
Unilateral pulmonary edema
(as in some cases of mitral regurgitation)
Re-expansion pulmonary edema
Aspiration pneumonitis
Postobstructive pneumonia
Bronchogenic carcinoma
Pulmonary embolism (oligemia on the affected side may be misinterpreted as diffuse
opacity on the unaffected side)
Bronchopneumonia
Tuberculosis
Bronchogenic
carcinoma with metastasis
Pneumoconiosis
Septic emboli
Allergic bronchopulmonary aspergillosis
Sarcoidosis
Organizing pneumonia
Vasculitis
Aspiration pneumonitis
Pneumonia
Bronchogenic carcinoma
Aspiration pneumonia
Pulmonary embolism
Zonal predilection:
Upper-tuberculosis,
pneumoconiosis, right upper lobe edema in acute mitral
regurgitation
Lower-aspiration
pneumonia, asbestosis

ARDS, acute respiratory distress syndrome;

PJP, Pneumocystis jirovecii pneumonia