Fig. 2.

Results from mediation analysis. The conditional process diagrams present standardized β FC on rWML-cognitive relationships in the DMN. The mediating effects of both cluster connectivity (WCC, a) and mean connectivity (MCS, b) are provided. The average causal mediation effects (ACME), average direct effects (ADE), and total effect point estimates are shown, as are 95% confidence intervals. DMN, default mode network; MCS, mean connectivity score; rWML, regional white matter lesion volume; WCC, WML-related cluster connectivity; MoCA. Montreal Cognitive Assessment