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Figure 1. Diagram of patients enrolled in this study. In total, 1,721 patients underwent surgery due to primary breast cancer at Yokohama Rosai Hospital between April 2012 and May 2020. Of these, 1,121 patients had ER-positive/HER2-negative disease, and 95 patients among them submitted to Oncotype DX testing were enrolled in this retrospective study. DCIS: Ductal carcinoma in situ; ODX: Oncotype DX.