Table II. Pharmacokinetic parameters of methotrexate (MTX) after intravenous administration at 1,000 mg/kg alone and in combination with 100 mg/kg glycyrrhizin (GZ).

AUC_∞: Area under the concentration-time curve at infinity; C₀: drug concentration at time 0; CL_t: total clearance; t_1/2α/t_1/2β: terminal halflife of α phase/β phase; V_c: volume of the central compartment or the initial volume of distribution; V_ss: steady-state volume of distribution; V_β: apparent volume of distribution in the post-distributional phase; Each point represents the mean±S.D. of four rats. Statistically significant p-values are shown in bold.