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. Author manuscript; available in PMC: 2021 Jul 18.
Published in final edited form as: Nat Med. 2020 May 11;26(5):693–698. doi: 10.1038/s41591-020-0860-1

Extended Data Fig. 4. Elevated on-treatment pIL8 is associated with poor clinical outcome.

Extended Data Fig. 4

Association between high vs low ratio of pIL8 levels on treatment cycle 3 day 1 (C3D1) and baseline (C1D1) and Objective Response Rate (ORR) in a, cohort 1, b, cohort 2 of IMvigor210. High ratios were associated with a higher number of nonresponders (SD and PD) in cohort 1 (P= 0.042, two-sided Fisher’s exact test) and cohort 2 (P= 0.027, two-sided Fisher’s exact test) of IMvigor210. c, Kaplan-Meier curves depict OS of C3D1 and C1D1 ratio of pIL8 levels in cohort 1 of IMvigor210 (HR: 4.98, 95% CI: 1.83, 13.5, P=0.0016). Hazard ratios (HRs) and their 95% confidence intervals (CIs) were calculated using stratified Cox proportional hazards regression models, and p values were calculated using stratified log-rank test. HR and p value are adjusted for sex, age, race, ECOG performance status, presence of liver metastasis, and tumor burden (sum of longest diameter, SLD). d, High ratios were significantly associated with a higher number of nonresponders (SD and PD) in atezolizumb (P=8.22e-4, two-sided Fisher’s exact test) and but not in chemotherapy (P=0.060, two-sided Fisher’s exact test) arms of IMvigor211. e, The absolute lymphoid and myeloid counts in patients in atezolizumb (n=443) and chemotherapy (n=425) arms IMvigor211. Absolute lymphocyte counts: Atezo, C1D1: minima: 0, maxima: 3.74, Percentile 75%: 1.70, 50%: 1.32, 25%: 1.00. Atezo, C3D1: minima: 0, maxima: 3.5, Percentile 75%: 1.75, 50%: 1.38, 25%: 1.00. Chemo, C1D1: minima: 0, maxima: 4.08, Percentile 75%: 1.70, 50%: 1.20, 25%: 0.90. Chemo, C3D1: minima: 0, maxima: 3.89, Percentile 75%: 1.81, 50%: 1.40, 25%: 1.00. Absolute monocyte counts: Atezo, C1D1: minima: 0, maxima: 2.25, Percentile 75%: 0.80, 50%: 0.61, 25%: 0.49. Atezo, C3D1: minima: 0, maxima: 2.2, Percentile 75%: 0.82, 50%: 0.61, 25%: 0.49. Chemo, C1D1: minima: 0, maxima: 2.2, Percentile 75%: 0.82, 50%: 0.61, 25%: 0.49. Chemo, C3D1: minima: 0, maxima: 3.08, Percentile 75%: 0.90, 50%: 0.70, 25%: 0.50. P values are calculated by two-sided Mann-Whitney U-tests.

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