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. Author manuscript; available in PMC: 2021 Jul 18.
Published in final edited form as: Nat Med. 2020 May 11;26(5):693–698. doi: 10.1038/s41591-020-0860-1

Extended Data Fig. 5. Single cell RNAseq profiles of PBMC from bladder patients in IMvigor210 trial.

Extended Data Fig. 5

UMAP plot of the mUC PBMCs, with each cell in the entire single cell RNAseq color coded for (left to right): a, responses (Responders (n=7903) and nonresponders (n=6571)); b, the corresponding patient R1 (n=2761), R2 (n=1522), R3 (n=463), R4 (n=1194), R5 (n=1963) and NR1 (n=3189), NR2 (n=849), NR3 (n=1018), NR4 (n=697), NR5 (n=818) and c, the number of transcripts detected in that cell (log 10 scale). d, the fraction of cells originating from responders and nonresponders; e, the fraction of cells originating from each of the 10 patients; f, box plots of the number of transcripts (log10) across all different cell types. Monocytes (n=6761), minima: 2.92, maxima: 4.35, and Percentile 75%: 3.59, 50%: 3.39, 25%: 3.20. CD16 Monocytes (n=623), minima: 2.92, maxima: 3.65, and Percentile 75%: 3.29, 50%: 3.23, 25%: 3.16. DC-like (n=305), minima: 2.96, maxima: 4.17, and Percentile 75%: 3.55, 50%: 3.35, 25%: 3.19. DC (n=391), minima: 2.95, maxima: 3.65, and Percentile 75%: 3.24, 50%: 3.17, 25%: 3.09. Megakaryocyte (n=294), minima: 2.94, maxima: 3.67, and Percentile 75%: 3.67, 50%: 3.19, 25%: 3.11. CD8+ T cells (n=565), minima: 2.93, maxima: 4.15, and Percentile 75%: 3.61, 50%: 3,42, 25%: 3.21. CD8+ Tcm (n=1388), minima: 2.93, maxima: 4.22, and Percentile 75%: 3.51, 50%: 3.34, 25%: 3.19. CD8+ Tem (n=1194), minima: 2.92, maxima: 4.10, and Percentile 75%: 3.56, 50%: 3,38, 25%: 3.20. CD4+ T cells (n=443), minima: 2.94, maxima: 4.02, centre: 0.75 and Percentile 75%: 3.58, 50%: 3.39, 25%: 3.21. CD4+ Tcm (n=451), minima: 2.91, maxima: 4.45, and Percentile 75%: 3.54, 50%: 3.32, 25%: 3.18. CD4+ Tem (n=335), minima: 2.93, maxima: 4.06, and Percentile 75%: 3.47, 50%: 3.28, 25%: 3.15. Tregs (n=238), minima: 2.90, maxima: 4.15, and Percentile 75%: 3.49, 50%: 3.30, 25%: 3.14. NK cells (n=1099), minima: 2.90, maxima: 4.27, and Percentile 75%: 3.56, 50%: 3.36, 25%: 3.16. B cells (n=387), minima: 2.91, maxima: 3.96, and Percentile 75%: 3.51, 50%: 3.32, 25%: 3.19, g, UMAP plot shows the distribution of different cell types between responders and non responders. Responders (n=7903) and nonresponders (n=6571).