Table 4.
BMDS modeling of cancer incidence in male rats using the MS Combo model. Neoplasm incidence data modeled here did not include the highest exposure dose of 6 W/kg
| Exposure condition and tumor type | BMD5 | BMDL5 | BMD10 | BMDL10 |
|---|---|---|---|---|
| CDMA, heart schwannoma | 4.09a | 2.12 | 8.41a | 3.50 |
| CDMA, pituitary gland adenoma | 0.60 | 0.37 | 1.23 | 0.77 |
| CDMA, liver adenoma | 3.37a | 1.84 | 6.93a | 3.78 |
| CDMA, combined heart schwannoma, liver adenoma, and pituitary gland adenoma | 0.45 | 0.31 | 0.93 | 0.63 |
| GSM, heart schwannoma | 6.87a | 3.01 | Could not be modeled | |
| GSM, brain malignant glioma | 3.40a | 1.86 | 6.99a | 3.46 |
| GSM, brain meninges neoplasm (benign and malignant) | 4.21a | 1.90 | Could not be modeled | |
| GSM, adrenal medulla pheochromocytoma (benign and malignant) | 0.58 | 0.38 | 1.20 | 0.78 |
| GSM, pituitary gland adenoma | 1.06 | 0.51 | 2.17 | 1.06 |
| GSM, combined heart schwannoma, brain glioma, and meninges neoplasm, adrenal pheochromocytoma, and pituitary gland adenoma | 0.30 | 0.21 | Could not be modeled | |
a Calculated BMD value is greater than the 3 W/kg highest exposure dose included in this analysis