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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Semin Cell Dev Biol. 2020 Jul 27;109:96–105. doi: 10.1016/j.semcdb.2020.06.014

Figure 3.

Figure 3.

Structural features of RIPKs. A) The size and flexibility of the side chains of Met92 gatekeeper and Leu157 of the DLG define access into the allosteric back-pocket of RIPK1. Based on Glu-in/DLG-out structure 4NEU. Figures were generated using the Schrödinger Maestro software package. B) Arg142 of the HRD motif of RIPK3 is in sufficient proximity to Ser165 in the activation loop. We propose that phosphorylation of Ser165 will result in mutual rotation (arrow) of the two side chains to enable interaction. Based on the active Glu-in/DFG-in structure 4M66.