Table 2.
Comparative Band Intensities of Phospho as Well as Total p53 Proteins as Obtained from Western Blot Analysis in Presence of Either Curcumin or Aurora-A Inhibitor I
| MCF-7 | MCF-7Dox/R | |||
|---|---|---|---|---|
| Treatment Duration |
Phospho p53/Total p53 | Phospho p53/Total p53 | Phospho p53/Total p53 | Phospho p53/Total p53 |
| (Treatment with Curcumin at 25 µM) | (Treatment with Aurora A inhibitor I at 3 nM) | (Curcumin Treatment at 25 µM) | (Treatment with Aurora A inhibitor I at 3 nM) | |
| 0h | 3.48±0.5 | 3.86±0.4 | 5.45±0.5 | 5.12±0.4 |
| 4h | 1.3±0.32 | 1.63±0.2 | 2.6±0.32 | 2.4±0.2 |
| 8h | 0.82±0.05 | 0.98±0.04 | 1.32±0.09 | 1.15±0.04 |
| 12h | 0.42±0.03 | 0.62±0.02 | 0.6±0.05 | 0.39±0.02 |
| 16 | 0.18±0.03 | 0.15±0.02 | 0.35±0.03 | 0.24±0.02 |