Table 2.

Top 20 Pathways in Uveitis Identified by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways

Pathway	Description	Number of Genes	Significantly Up	Significantly Down	P Value
path:hsa05168	Herpes simplex virus 1 infection	445	43	105	<.001
path:hsa05152	Tuberculosis	146	47	5	<.001
path:hsa04145	Phagosome	126	42	1	<.001
path:hsa05164	Influenza A	130	42	4	<.001
path:hsa04380	Osteoclast differentiation	115	39	5	<.001
path:hsa04621	NOD-like receptor signaling pathway	146	45	5	<.001
path:hsa05167	Kaposi sarcoma-associated herpesvirus infection	153	46	4	<.001
path:hsa05130	Pathogenic Escherichia coli infection	162	47	3	<.001
path:hsa05131	Shigellosis	212	55	9	<.001
path:hsa04666	Fc gamma R-mediated phagocytosis	86	31	3	<.001
path:hsa05132	Salmonella infection	196	51	11	<.001
path:hsa04650	Natural killer cell mediated cytotoxicity	96	31	5	<.001
path:hsa05163	Human cytomegalovirus infection	181	46	5	<.001
path:hsa05140	Leishmaniasis	69	25	0	<.001
path:hsa04810	Regulation of actin cytoskeleton	163	42	3	<.001
path:hsa04062	Chemokine signaling pathway	141	38	3	<.001
path:hsa04630	JAK-STAT signaling pathway	103	31	7	<.001
path:hsa05135	Yersinia infection	111	32	4	<.001
path:hsa05150	Staphylococcus aureus infection	48	19	0	<.001
path:hsa04670	Leukocyte transendothelial migration	81	25	6	<.001

JAK-STAT = Janus Kinase-signal Transducer and Activator, NOD = Nucleotide oligomerization domain.

All the p values are <.001. The biological processes are listed from the most statistically significant (top) to least statistically significant (bottom).