Figure 1.

Schematic overview of the Acutelines biobank. By collecting data from prehospital up to long after hospital discharge, Acutelines follows the complete acute patient journey. Specially trained research assistants screen potential participants in the emergency department (ED) (24/7). Waveform data and vital parameters from bed-side monitors are captured automatically, and biomaterials (ie, blood, urine, faeces) will be collected while awaiting deferred consent (by proxy). ED facilities allow rapid processing and storage of biomaterials (−80°C). Wearable devices are used to continue capturing waveforms and vital parameters during the first 72 hours of hospital admission. Connections with the electronic health record and external databases (eg, GP, pharmacy, health insurance companies) allow to collect relevant clinical data when applicable for specific research questions, such as medication use and comorbidity up to 5 years after presentation. Digital survey-based patient-reported outcomes will be collected on fixed intervals and survival will be monitored indefinitely using the municipal registration. GP, general practitioner.