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. 2021 Jul 15;9(7):e002707. doi: 10.1136/jitc-2021-002707

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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A schematic presentation of a PeptiBAC cancer vaccine platform. Tumor antigens can readily be attached to the mycobacterial outer membrane of BCG using a cell penetrating peptide (CPP) sequence or a poly-lysine sequence as an anchoring moiety. Anchor-modified peptides are complexed for 15 min with BCG for efficient attachment. Unbound peptides are removed by pelleting the bacteria followed by buffer exchange. Various different peptides, including MHC class I and II epitopes, can be delivered by the PeptiBAC platform for potent activation of antigen-presenting cells and increased antigen-specific immunological responses. MHC, major histocompatibility complex; PeptiBAC, peptide-coated Bacillus Calmette-Guérin.