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. 2021 Jul 15;9(7):e002707. doi: 10.1136/jitc-2021-002707

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Antigen-presenting cells can readily cross-present antigens delivered by the PeptiBAC platform. Mouse dendritic cell line Jaws II was pulsed with PeptiBAC-OVA, BCG, CPP-containing SIINFEKL peptide alone or left unpulsed (cells only). Cross-presentation was determined by flow cytometry using APC-conjugated anti-H-2Kb bound to SIINFEKL. CD86 and CD40 expression (as a measure of dendritic cell maturation and activation) was determined by flow cytometry. Each bar is the mean±SEM of technical triplicates. Statistical analysis was performed with one-way analysis of variance. ****p<0.0001. APC, antigen-presenting cell; CPP, cell penetrating peptide; PeptiBAC, peptide-coated Bacillus Calmette-Guérin; PeptiBAC-OVA, OVA-targeting PeptiBAC.