Figure 1. G protein-dependent signalling.

Schematic diagram of the distinct signalling pathways upon chemokine receptor activation through G proteins (Abbreviations: ATP, adenosine triphosphate; cAMP, cyclic adenosine monophosphate; DAG, diacylglycerol; GDP, guanosine diphosphate; GEF, guanine nucleotide exchange factor; GTP, guanosine triphosphate; IP₃, inositol trisphosphate; MAPKs, mitogen-activated protein kinases; PI3Ks, phosphoinositide 3-kinases; PIP₂, phosphatidylinositol (4,5)-bisphosphate; PIP₃, phosphatidylinositol (3,4,5)-trisphosphate; PKA, protein kinase A; PKC, protein kinase C).