Table 1. Primary hit list.
Compound | Cas No | Fluorescence | % Reduction at 4 µM | % Reduction at 0.8 µM |
---|---|---|---|---|
Z-DEVD-FMK | 210344-95-9 | normal | 100 | 53 |
Z-IETD-FMK | 210344-98-2 | normal | 100 | 50 |
Z-VAD(OMe)-FMK | 187389-52-2 | normal | 100 | 43 |
Adapalene | 106685-40-9 | HIGH | 87 | 0 |
Prazosin hydrochloride | 19237-84-4 | HIGH | 80 | 0 |
CH-223191 | 301326-22-7 | normal | 79 | 0 |
3,9-dihydroxy-2-(3-methyl-2-butenyl)-6H-[1]benzofuro[3,2-c]chromen-6-one | 18642-23-4 | HIGH | 79 | 0 |
JD-5037 | 1392116-14-1 | HIGH | 74 | 0 |
Go6976 | 136194-77-9 | moderate | 67 | 0 |
Tariquidar | 206873-63-4 | HIGH | 66 | 0 |
ETP-46464 | 1345675-02-6 | HIGH | 64 | 0 |
PDK1/Akt/Flt Dual Pathway Inhibitor | 331253-86-2 | moderate | 64 | 0 |
Doxazosin (mesylate) | 77883-43-3 | HIGH | 60 | 0 |
NVP-BVU972 | 1185763-69-2 | HIGH | 59 | 0 |
2S)-2-(acetylamino)-N-[(1S)-1-({[(1S)-1-formylpentyl]amino}carbonyl)-3-methylbutyl]-4-methylpentanamid | 110044-82-1 | normal | 58 | 0 |
Marbofloxacin | 115550-35-1 | moderate | 56 | 0 |
STF-118804 | 894187-61-2 | HIGH | 55 | 0 |
CPI-613 | 95809-78-2 | HIGH | 54 | 0 |
Bromoenol lactone | 88070-98-8 | normal | 49 | 0 |
Fatostatin HBr | 298197-04-3 | normal | 48 | 0 |
Sotagliflozin (LX4211) | 1018899-04-1 | normal | 47 | 0 |
Tyrphostin AG 1296 | 146535-11-7 | moderate | 45 | 0 |
Alfuzosin | 81403-80-7 | HIGH | 44 | 0 |
Palomid 529 | 914913-88-5 | HIGH | 43 | 0 |
1-Allyl-3,7-dimethyl-8-p-sulfophenylxanthine | 149981-25-9 | moderate | 37 | 0 |
Granisetron HCl | 107007-99-8 | HIGH | 36 | 0 |
Curcumol | 4871-97-0 | HIGH | 31 | 0 |