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An amount of 10 µM of each compounds were used. (A) PLpro DUB activities. PLpro cleaves K48-linked Ub3 to Ub2 and Ub1. These activities were inhibited strongly by beta-lapachone and dihydrotanshinone I, moderately by Ro 08-2750 and GRL-0617, but not by shikonin. (B) PLpro deISGylating activities. Pro-ISG15 is being cleaved to ISG15 by PLpro. Similar observation as in A.
