Fig. 1.

The scheme of the FRMB system, including the all-fiber optical system, the microfluidic chip, fiber bio-probe, and the fluidics (pump and valve). The incident light couples into the multi-mode fiber bio-probe through the multi-mode fiber of the SMFC, and at the distal end surface of bio-probe, part of incident light reflects back to the bio-probe based on Fresnel reflection mechanism and is detected by the PD-1000 detector. Various solutions are introduced into the microfluidic cell under the control of six-channel valve