Table S2. Discrimination ability of the reference and full (reference model + IS-mod) models in two cohorts.

Variables	Discovery cohort			Validation cohort
	Reference model	Full model		Reference model	Full model
AUC, area under the receiver operating characteristic curve; iAUC, integrated AUC.
C-index	0.709 (0.652−0.761)	0.752 (0.700−0.804)		0.705 (0.615−0.795)	0.759 (0.672−0.845)
AUC at 5-year	0.745 (0.675−0.814)	0.797 (0.735−0.860)		0.742 (0.644−0.840)	0.806 (0.717−0.894)
iAUC	0.746	0.775		0.767	0.788